Hero Wines: Chardonnay, Carbernet Sauvignon, Shiraz, Sauvignon and Semillon. The Margaret River Wine Region is celebrated worldwide as a bucket-list destination, famous for its esteemed wines, gourmet produce and breathtaking beaches. Take your time to explore this vast wine region and all the natural beauty that compliments the premium wines it is famous for. Margaret River has no official sub-regions but it does have distinctions based on climate and soil differences: Yallingup, Carbunup, Wilyabrup, Treeton, Wallcliffe and Karridale. Make sure you make a reservation to experience these prestigious wine makers. Visit Vasse Felix - Margaret River’s first vineyard established in 1967. They have a selection of wine experiences, a restaurant and an art gallery to keep you busy. Accommodation: Smiths Beach Resort on the coast or Cape Lodge.